Elucidation of co-operative roles of non-specific interactions for poly(ethylene glycol) specific interactions and responses

Poly（ethylene glycol）s（PEGs） have been the most widely used polymer, and PEGylation onto proteins, as well as nanoparticles has become a gold standard technique. PEGs have a long history of safe use in humans, however, induction of anti-PEG antibodies was observed in not only patients, who received...

Full description

Saved in:
Bibliographic Details
Published inDrug Delivery System Vol. 37; no. 2; pp. 122 - 130
Main Author Shiraishi, Koichi
Format Journal Article
LanguageJapanese
Published Kawasaki THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM 25.03.2022
Japan Science and Technology Agency
Subjects
anti-PEG antibody
Antibodies
Biomedical materials
Clinical trials
material symbiosis
Nanoparticles
non-specific interactions
Poly(ethylene glycol)
Polyethylene glycol
Polymers
specific interactions
Online AccessGet full text

Cover

More Information
Summary:Poly（ethylene glycol）s（PEGs） have been the most widely used polymer, and PEGylation onto proteins, as well as nanoparticles has become a gold standard technique. PEGs have a long history of safe use in humans, however, induction of anti-PEG antibodies was observed in not only patients, who received PEGylated therapeutics, but also healthy subjects. As many more PEGylated therapeutics have been examined in clinical trials, a better understanding of PEG-related interactions, as well as responses is crucial for development of not only PEGylated therapeutics, but also materials in biomedical fields. The current review summarizes PEG-related specific interactions. Two step interactions are suggested to understand why PEG-conjugates exhibit irreversible bindings, whereas PEGs exhibit only rapid/weak interactions. The current review uncovers PEG-related interactions, and understanding of roles of PEGs will be beneficial for further development of biopharmaceutics.
ISSN:0913-5006
1881-2732
DOI:10.2745/dds.37.122