Enhancing therapy with nano-based delivery systems: exploring the bioactive properties and effects of apigenin

Apigenin, a potent natural flavonoid, has emerged as a key therapeutic agent due to its multifaceted medicinal properties in combating various diseases. However, apigenin's clinical utility is greatly limited by its poor water solubility, low bioavailability and stability issues. To address the...

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Bibliographic Details
Published inTherapeutic delivery Vol. 15; no. 9; p. 717
Main Authors Kumar, Girish, Jain, Pushpika, Virmani, Tarun, Sharma, Ashwani, Akhtar, Md Sayeed, Aldosari, Saad A, Khan, Mohd Faiyaz, Duarte, Sofia O D, Fonte, Pedro
Format Journal Article
LanguageEnglish
Published England 2024
Subjects
Animals
Apigenin - administration & dosage
Apigenin - chemistry
Apigenin - pharmacokinetics
Apigenin - pharmacology
Biological Availability
Drug Delivery Systems - methods
Humans
Nanoparticle Drug Delivery System - chemistry
Nanoparticles - chemistry
Nanotechnology - methods
Solubility
therapeutics
bioavailability
nanocarriers
apigenin
flavonoid
polymers
stability
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Summary:Apigenin, a potent natural flavonoid, has emerged as a key therapeutic agent due to its multifaceted medicinal properties in combating various diseases. However, apigenin's clinical utility is greatly limited by its poor water solubility, low bioavailability and stability issues. To address these challenges, this review paper explores the innovative field of nanotechnology-based delivery systems, which have shown significant promise in improving the delivery and effectiveness of apigenin. This paper also explores the synergistic potential of co-delivering apigenin with conventional therapeutic agents. Despite the advantageous properties of these nanoformulations, critical challenges such as scalable production, regulatory approvals and comprehensive long-term safety assessments remain key hurdles in their clinical adoption which must be addressed for commercialization of apigenin-based formulations.
ISSN:2041-6008
DOI:10.1080/20415990.2024.2386928