Inspiratory muscle training enhances pulmonary O 2 uptake kinetics and high-intensity exercise tolerance in humans

• Published in: Journal of applied physiology (1985) Vol. 109; no. 2; pp. 457 - 468
• Main Authors: Bailey, Stephen J., Romer, Lee M., Kelly, James, Wilkerson, Daryl P., DiMenna, Fred J., Jones, Andrew M.
• Format: Journal Article
• Language: English
• Published: 01.08.2010
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00077.2010

Fatigue of the respiratory muscles during intense exercise might compromise leg blood flow, thereby constraining oxygen uptake (V̇o 2 ) and limiting exercise tolerance. We tested the hypothesis that inspiratory muscle training (IMT) would reduce inspiratory muscle fatigue, speed V̇o 2 kinetics and enhance exercise tolerance. Sixteen recreationally active subjects (mean ± SD, age 22 ± 4 yr) were randomly assigned to receive 4 wk of either pressure threshold IMT [30 breaths twice daily at ∼50% of maximum inspiratory pressure (MIP)] or sham treatment (60 breaths once daily at ∼15% of MIP). The subjects completed moderate-, severe- and maximal-intensity “step” exercise transitions on a cycle ergometer before (Pre) and after (Post) the 4-wk intervention period for determination of V̇o 2 kinetics and exercise tolerance. There were no significant changes in the physiological variables of interest after Sham. After IMT, baseline MIP was significantly increased (Pre vs. Post: 155 ± 22 vs. 181 ± 21 cmH 2 O; P < 0.001), and the degree of inspiratory muscle fatigue was reduced after severe- and maximal-intensity exercise. During severe exercise, the V̇o 2 slow component was reduced (Pre vs. Post: 0.60 ± 0.20 vs. 0.53 ± 0.24 l/min; P < 0.05) and exercise tolerance was enhanced (Pre vs. Post: 765 ± 249 vs. 1,061 ± 304 s; P < 0.01). Similarly, during maximal exercise, the V̇o 2 slow component was reduced (Pre vs. Post: 0.28 ± 0.14 vs. 0.18 ± 0.07 l/min; P < 0.05) and exercise tolerance was enhanced (Pre vs. Post: 177 ± 24 vs. 208 ± 37 s; P < 0.01). Four weeks of IMT, which reduced inspiratory muscle fatigue, resulted in a reduced V̇o 2 slow-component amplitude and an improved exercise tolerance during severe- and maximal-intensity exercise. The results indicate that the enhanced exercise tolerance observed after IMT might be related, at least in part, to improved V̇o 2 dynamics, presumably as a consequence of increased blood flow to the exercising limbs.