The influence of genetic factors on the effectiveness, safety and tolerability of antiretroviral therapy in patients with hiv infection

This article provides an overview of the existing literature on the pharmacogenetic determinants of exposure and toxicity of antiretroviral drugs, as well as on genetic markers associated with the rate of disease progression. In addition, this article looks at current clinical opportunities as well...

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Published inZhurnal infektologii Vol. 13; no. 1; pp. 21 - 28
Main Authors Kanestri, V. G., Shakhgildyan, V. I., Kravchenko, A. V., Konnov, D. S., Popova, A. A.
Format Journal Article
LanguageEnglish
Russian
Published Journal Infectology 30.03.2021
Subjects
comorbidities
genetic
hiv infection
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Summary:This article provides an overview of the existing literature on the pharmacogenetic determinants of exposure and toxicity of antiretroviral drugs, as well as on genetic markers associated with the rate of disease progression. In addition, this article looks at current clinical opportunities as well as genetics in HIV drug development. Large-scale, integrated approaches to the genome are expected to significantly change the knowledge landscape in the future.
ISSN:2072-6732
DOI:10.22625/2072-6732-2021-13-1-21-28