Innovative strategies for the discovery of new drugs against alopecia areata: taking aim at the immune system

• Published in: Expert opinion on drug discovery p. 1
• Main Authors: Guo, Hong-Wei, Ye, Zhi-Ming, Chen, Si-Qi, McElwee, Kevin J
• Format: Journal Article
• Language: English
• Published: England 01.11.2024
• Subjects: hair follicles; drug development; hair regrowth; disease pathogenesis; autoimmune disease; disease models; immune privilege; JAK inhibitors; Alopecia areata
• ISSN: 1746-045X
• DOI: 10.1080/17460441.2024.2409660

The autoimmune hair loss condition alopecia areata (AA) exacts a substantial psychological and socioeconomic toll on patients. Biotechnology companies, dermatology clinics, and research institutions are dedicated to understanding AA pathogenesis and developing new therapeutic approaches. Despite recent efforts, many knowledge gaps persist, and multiple treatment development avenues remain unexplored. This review summarizes key AA disease mechanisms, current therapeutic methods, and emerging treatments, including Janus Kinase (JAK) inhibitors. The authors determine that innovative drug discovery strategies for AA are still needed due to continued unmet medical needs and the limited efficacy of current and emerging therapeutics. For prospective AA treatment developers, the authors identify the pre-clinical disease models available, their advantages, and limitations. Further, they outline treatment development opportunities that remain largely unmapped. While recent advancements in AA therapeutics are promising, challenges remain, including the lack of consistent treatment efficacy, long-term use and safety issues, drug costs, and patient compliance. Future drug development research should focus on patient stratification utilizing robust biomarkers of AA disease activity and improved quantification of treatment response. Investigating superior modes of drug application and developing combination therapies may further improve outcomes. Spirited innovation will be needed to advance more effective treatments for AA.