Isolation, derivatization, and anti-microbial evaluation of secondary metabolites from Garcinia dryobalanoides

• Published in: Natural product research pp. 1 - 7
• Main Authors: Zaine, Nur Fazlin Zafirah, Zamakshshari, Nor Hisam, Abd Halim, Ainaa Nadiah, Yi Mian, Vivien Jong, Ngui Sing, Ngieng
• Format: Journal Article
• Language: English
• Published: England 26.06.2024
• Subjects: Secondary metabolites; antibacterial; SAR study; rubraxanthone derivatives; Garcinia dryobalanoides
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2024.2371109

A detailed study on secondary metabolites from the stem bark of has yielded one triterpenoid and four xanthones. Along with that, five novel rubraxanthone derivatives had been successfully synthesised Williamson etherification with various alkyl halides. The antibacterial evaluation on crude extract, isolated secondary metabolites , and synthesised compounds against , and demonstrated moderate to active activities outlining their bacteriostatic potential. The structure-activity relationship (SAR) study conducted revealed the presence of prenyl and hydroxy groups on the xanthone attributed to good bacterial inhibition. The introduction of the alkyl chain to the hydroxy part eventually decreases the antibacterial activity of the compound which is probably due to the bulkiness that causes steric hindrances, therefore limiting the ability to bind to its target site within the bacterial cell.