Joint health and pain in the changing hemophilia treatment landscape

• Published in: Expert review of hematology Vol. 17; no. 8; p. 431
• Main Authors: Mancuso, Maria Elisa, McLaughlin, Paul, Forsyth, Angela L, Valentino, Leonard A
• Format: Journal Article
• Language: English
• Published: England 02.08.2024
• Subjects: Hemarthrosis - diagnosis; Hemarthrosis - etiology; Hemarthrosis - therapy; Hemophilia A - complications; Hemophilia A - therapy; Humans; Joint Diseases - diagnosis; Joint Diseases - etiology; Joint Diseases - therapy; Pain - etiology; Pain Management - methods; Quality of Life; hemophilia; treatment; pain; bleeding; joints; physiotherapy; synovitis; Arthropathy
• ISSN: 1747-4094
• DOI: 10.1080/17474086.2024.2378936

Hemophilia is an inherited bleeding disorder. Bleeding, and in particular joint hemorrhage results in chronic arthropathy and disability. Acute and chronic pain are frequent and limit activity and participation and result in decreased health-related quality of life. Remarkable progress has been made in the diagnosis and treatment of hemophilia but bleeding continues to prove recalcitrant to currently available treatments and joint disease remains problematic. Physiotherapy and pain management are mainstays of current multidisciplinary integrated care of people with hemophilia (PWH). The focus of this review is on preservation of joint health in the era of new and innovative therapies. A search of the PubMed Central was conducted on 1 February 2024 using the MeSH Major Topic terms identified as keywords for the manuscript. This review will highlight what is known and unknown about joint bleeding and arthropathy, including insights on pain as a related complication. Recent advances in therapeutic interventions aimed at promoting healthy joints in PWH will be discussed, including both the pharmacological treatment landscape and related strategies to promote joint health.