Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction

• Published in: Journal of Zhejiang University. Science Vol. 4; no. 6; pp. 749 - 752
• Main Author: 罗本燕 陈智 陈峰 李霞 潘小平
• Format: Journal Article
• Language: English
• Published: China 01.11.2003
• Subjects: Aged; Apolipoproteins E - blood; Apolipoproteins E - genetics; Case-Control Studies; Cerebral Infarction - blood; Cerebral Infarction - genetics; Female; Gene Frequency; Humans; Intracranial Arteriosclerosis - blood; Intracranial Arteriosclerosis - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Sequence Analysis, DNA - methods; 动脉粥样硬化; 基因测序; 聚合酶链反应; 脑梗塞; 遗传多态性; 阿朴脂蛋白E基因
• ISSN: 1009-3095
• DOI: 10.1631/jzus.2003.0749

Objective : To explore the frequency and significance of ApoE gene polymorphisms in Chinese patiems with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P <0.05) . The preva-lence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group ( P =0.011 ). Conclusions : 465 C/G, 462C/G and 451 delC polymorphisms might be associated with ACI. 486GT allele might have protective effect on the pathogenesis of ACI.