Synergistic Inhibition of Both P2Y 1 and P2Y 12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis

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Bibliographic Details
Published inArteriosclerosis, Thrombosis, and Vascular Biology Vol. 36; no. 3; pp. 501 - 509
Main Authors Gremmel, Thomas, Yanachkov, Ivan B., Yanachkova, Milka I., Wright, George E., Wider, Joseph, Undyala, Vishnu V.R., Michelson, Alan D., Frelinger, Andrew L., Przyklenk, Karin
Format Journal Article
LanguageEnglish
Japanese
Published Ovid Technologies (Wolters Kluwer Health) 01.03.2016
Subjects
Adenosine Diphosphate
Adenosine Monophosphate
Adult
Animals
Aspirin
Blood Coagulation
Blood Platelets
Coronary Thrombosis
Dinucleoside Phosphates
Disease Models, Animal
Dogs
Dose-Response Relationship, Drug
Female
Fibrinolytic Agents
Humans
Male
Platelet Aggregation
Platelet Aggregation Inhibitors
Platelet Function Tests
Purinergic P2Y Receptor Antagonists
Rats, Sprague-Dawley
Receptors, Purinergic P2Y1
Receptors, Purinergic P2Y12
Time Factors
Young Adult
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More Information
ISSN:1079-5642
1524-4636
DOI:10.1161/atvbaha.115.306885