Unveiling Extracellular Inorganic Phosphate Signals from Blood in Human Cardiac 31P NMR Spectra

31P NMR spectra of the human heart are usually contaminated by signals that originate from blood. The main blood signals are 2,3-diphosphoglycerate (2,3-DPG), which overlap and sometimes obscure the signal of myocardial inorganic phosphate used to calculate intracellular pH and to monitor metabolic...

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Bibliographic Details
Published inJournal of cardiovascular magnetic resonance Vol. 3; no. 4; pp. 325 - 329
Main Authors Schmidt, Oliver, Bunse, Michael, Dietze, Günther J., Lutz, Otto, Jung, Wulf-Ingo
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 2001
Subjects
2,3-Diphosphoglycerate - blood
Adenosine Triphosphate - blood
Humans
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Male
Myocardium - metabolism
Phosphates - blood
Phosphocreatine - blood
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Summary:31P NMR spectra of the human heart are usually contaminated by signals that originate from blood. The main blood signals are 2,3-diphosphoglycerate (2,3-DPG), which overlap and sometimes obscure the signal of myocardial inorganic phosphate used to calculate intracellular pH and to monitor metabolic changes in the heart. In this work we demonstrate, first, that even without proton decoupling the resolution of such spectra can be high enough to evaluate intracellular inorganic phosphate of myocardium in about 70% of the spectra and, second, that extracellular inorganic phosphate from blood contributes a signal in the chemical shift region of the 2-phosphate signal of 2,3-DPG.
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ISSN:1097-6647
1532-429X
DOI:10.1081/JCMR-100108586