Experimental Adaptation of Staphylococcus Aureus to Sulfuryl Derivatives of Benzazolides

• Published in: Pharmaceutical chemistry journal Vol. 42; no. 7; pp. 377 - 381
• Main Authors: Selezneva, E. S., Ten’gaev, E. I.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2008
• Subjects: Medicine; Molecular-Biological Problems of Drug Design and Mechanism of Drug Action; Organic Chemistry; Pharmacology/Toxicology; Pharmacy; Staphylococcus aureus
• ISSN: 0091-150X; 1573-9031
• DOI: 10.1007/s11094-008-0136-4

A state of pre-adaptation to highly toxic doses of sulfuryl derivatives of benzimidazole and benzotriazole was developed in Staphylococcus aureus species by treating them with non-toxic doses of these compounds. Pre-treatment of S. aureus with the starting benzazolides (benzimidazole and benzotriazole) also created the pre-adaptation to their sulfuryl derivatives. Experiments on cross-pre-adaptation where the pre-adaptation to sulfuryl derivatives of benzazolides was created by the action of non-toxic doses of benzotriazole and vice versa showed that the planar structures of the double ring of benzazolide plays a key role in activation of the repair systems of S. aureus . Mathematical analysis revealed a high nonlinear correlation between the ability of a compound to create the state of pre-adaptation in S. aureus culture on one hand and the physical and chemical properties such as the lipophilicity, molecular weight and volume, and hydration energy on the other.