Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses
Transdermal drug delivery using dissolving microneedles (DMNs) is promising due to increased patient compliance and safety. This article presents a comprehensive simulation and experimental analysis of DMNs with varying tip and base diameters and polymers. The objective of the simulation study is to...
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Published in | Journal of applied polymer science Vol. 141; no. 38 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Hoboken, USA
John Wiley & Sons, Inc
10.10.2024
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Transdermal drug delivery using dissolving microneedles (DMNs) is promising due to increased patient compliance and safety. This article presents a comprehensive simulation and experimental analysis of DMNs with varying tip and base diameters and polymers. The objective of the simulation study is to identify the optimal tip and base diameter of DMNs, as well as the most suitable polymer, for achieving maximum penetration depth. The simulation results showed that the compound consisting of polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) in a ratio of 2:1, with a tip radius of 17.5 μm and a base radius of 150 μm, achieved the deepest penetration among the different types of polymers investigated (including PVA, hyaluronic acid (HA), and PVA/PVP in ratios of 1:1 and 1:2). In addition, mechanical and skin penetration experiments were performed on PVA/PVP 2:1 DMNs with varying concentrations of 4, 7, 10, and 15% w/w to determine the optimal polymer concentration. The results of this study indicated that the optimal composition, considering the viscosity of the polymer solution and the simplicity of filling the silicone negative molds, is a PVA/PVP 2:1 with a concentration of 7% w/w.
Simulation and experimental analysis of dissolving microneedles insertion into the skin. |
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ISSN: | 0021-8995 1097-4628 |
DOI: | 10.1002/app.55973 |