Inhibitory effect of an extract containing lutein and zeaxanthin on retinal damage

N-retinylidene-N-retinyl-ethanolamine (A2E) is a component of lipofuscin that is characteristically observed in the retinal cells of patients with early age-related macular degeneration. It causes retinal tissue damage through photooxidation, generation of reactive oxygen species, and induction of i...

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Published inHan'guk Sikp'um Kwahakhoe Chi = Korean Journal of Food Science and Technology Vol. 55; no. 2; pp. 112 - 119
Main Authors Shin, Chae-Young, Sun, Eun-Mi, Min, Jihyun, Jeong, Kwang-Won
Format Journal Article
LanguageEnglish
Published Seoul Korean Society of Food Science & Technology 01.04.2023
Subjects
Accumulation
Age
Age related diseases
Animal tissues
Apoptosis
Damage
Effectiveness
Epithelium
Ethanolamine
Eye diseases
Gene expression
Inflammation
Irradiation
Lutein
Macular degeneration
Photooxidation
Radiation
Reactive oxygen species
Retina
Retinal cells
Retinal pigment epithelium
Zeaxanthin
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Summary:N-retinylidene-N-retinyl-ethanolamine (A2E) is a component of lipofuscin that is characteristically observed in the retinal cells of patients with early age-related macular degeneration. It causes retinal tissue damage through photooxidation, generation of reactive oxygen species, and induction of inflammation. In this study, we evaluated the efficacy of an extract containing lutein and zeaxanthin (LZ) by measuring A2E accumulation in retinal cells, changes in gene expression due to photooxidation, and damage to mouse retinal tissue in a model of retinal cell damage caused by blue light (BL). The results revealed that LZ inhibited the accumulation of A2E in retinal pigment epithelial cells, exhibited antioxidant effects and restored the expression levels of genes related to inflammation and apoptosis in retinal pigment epithelial cells with BL-induced damage. In addition, LZ reduced the number of lesions caused by BL irradiation, restored the thickness of the entire retina and the outer nuclear layer, and restored the expression of HMOX1, EYA3, and ATF6α in the retina. This study demonstrates the efficacy of LZ in BL models in vitro and in vivo. In addition, the in vivo results presented here are expected to facilitate the development of new markers for in vivo retinal damage in BL-induced models.
ISSN:0367-6293
2383-9635
DOI:10.9721/KJFST.2023.55.2.112