Diagnostic Accuracy of Contrast-Enhanced Thoracic Photon-Counting Computed Tomography for Opportunistic Locoregional Staging of Breast Cancer Compared With Digital Mammography: A Prospective Trial

• Published in: Investigative radiology Vol. 59; no. 7; p. 489
• Main Authors: Neubauer, Jakob, Wilpert, Caroline, Gebler, Oliver, Taran, Florin-Andrei, Pichotka, Martin, Stein, Thomas, Molina-Fuentes, Moisés Felipe, Weiss, Jakob, Juhasz-Böss, Ingolf, Bamberg, Fabian, Windfuhr-Blum, Marisa, Neubauer, Claudia
• Format: Journal Article
• Language: English
• Published: United States 01.07.2024
• Subjects: Adult; Aged; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - pathology; Contrast Media; Feasibility Studies; Female; Humans; Mammography - methods; Middle Aged; Neoplasm Staging; Photons; Prospective Studies; Radiography, Thoracic - methods; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed - methods
• ISSN: 1536-0210
• DOI: 10.1097/RLI.0000000000001051

Accurate locoregional staging is crucial for effective breast cancer treatment. Photon-counting computed tomography (PC-CT) is an emerging technology with high spatial resolution and the ability to depict uptake of contrast agents in tissues, making it a promising tool for breast cancer imaging. The aim of this study was to establish the feasibility of locoregional staging of breast cancer through contrast-enhanced thoracic PC-CT, assess its diagnostic performance, and compare it with that of digital mammography (DM). Patients with newly diagnosed breast cancer, DM, and indication of thoracic CT staging were prospectively enrolled in this clinical cohort study over a period of 6 months. Participants underwent contrast-enhanced thoracic PC-CT and breast magnetic resonance imaging in prone position. After blinding to patient data, 2 radiologists independently rated PC-CT and DM regarding the following 6 characteristics: (1) diameter of the largest mass lesion, (2) infiltration of cutis/pectoral muscle/thoracic wall, (3) number of mass lesions, (4) presence/absence of adjacent ductal carcinoma in situ (DCIS), (5) tumor conspicuity, and (6) diagnostic confidence. Reference standard was generated from consensus reading of magnetic resonance imaging combined with all histopathological/clinical data by an independent adjudication committee applying TNM eighth edition. Among 32 enrolled female subjects (mean ± SD age, 59 ± 13.0 years), diagnostic accuracy for T-classification was higher for PC-CT compared with DM (0.94 vs 0.50, P < 0.01). Moreover, the correlation of the number of detected tumor masses with the reference standard was stronger for PC-CT than for DM (0.72 vs 0.50, P < 0.01). We observed that PC-CT significantly ( P < 0.04) outperformed DM regarding not only sensitivity (0.83 and 0.25, respectively) but also specificity (0.99 and 0.80, respectively) for adjacent DCIS. The κ values for interreader reliability were higher for PC-CT compared with DM (mean 0.88 vs 0.54, respectively; P = 0.01). Photon-counting computed tomography outperformed DM in T-classification and provided higher diagnostic accuracy for the detection of adjacent DCIS. Therefore, opportunistic locoregional staging of breast cancer in contrast-enhanced thoracic PC-CT is feasible and could overcome limitations of DM with the potential to improve patient management.