Withdrawal of chronic beta-adrenoceptorblockade: effects on haemodynamics, blood lipids and haemostatic variables

The effect of cessation of chronic beta-adrenoceptorblockade on heart rate, blood pressure, blood lipids and selected haemostatic factors have been measured in 22 patients recovering from myocardial infarction. Clinical examination and blood tests were performed before and 12 weeks after withdrawal...

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Bibliographic Details
Published inEuropean journal of clinical pharmacology Vol. 39; no. 1; p. 81
Main Authors Smith, P, Seljeflot, I, Opstad, T
Format Journal Article
LanguageEnglish
Published Germany 01.10.1990
Subjects
Adrenergic beta-Antagonists - adverse effects
Adult
Aged
Blood Pressure - drug effects
Cholesterol - blood
Cholesterol, HDL - blood
Female
Heart Rate - drug effects
Hemodynamics - drug effects
Humans
Lipids - blood
Male
Middle Aged
Substance Withdrawal Syndrome - blood
Substance Withdrawal Syndrome - physiopathology
Triglycerides - blood
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Summary:The effect of cessation of chronic beta-adrenoceptorblockade on heart rate, blood pressure, blood lipids and selected haemostatic factors have been measured in 22 patients recovering from myocardial infarction. Clinical examination and blood tests were performed before and 12 weeks after withdrawal of beta-adrenoceptor-blockade, which had lasted for an average of 3 y. No effect was found on blood pressure. There was a significant increase in heart rate of 12%. Total cholesterol declined by 9%, high density lipoprotein (HDL-cholesterol) increased by 12%, and triglycerides decreased by 6%. The triglyceride dependent factors, plasminogen activator inhibitor (PAI-1) and factor VII-phospholipid complex, were not affected.
ISSN:0031-6970
DOI:10.1007/BF02657064