Intravenous Ketamine as an Adjunct for Pachyonychia Congenita-Associated Pain: A Case Report

Pachyonychia congenita (PC) is a rare, inherited disorder of keratin filaments characterized by palmoplantar hyperkeratosis, keratoderma, and extreme pain. Management is largely symptomatic and typically involves multimodal pain control strategies. Here, we report the treatment of one 21-year-old ma...

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Bibliographic Details
Published inA&A practice Vol. 13; no. 8; p. 319
Main Authors Paul, Jed M, Orlovich, Daniel S, Patton, John W, Qian, Xiang
Format Journal Article
LanguageEnglish
Published United States 15.10.2019
Subjects
Adult
Analgesics - therapeutic use
Humans
Infusions, Intravenous
Ketamine - therapeutic use
Male
Neuralgia - drug therapy
Pachyonychia Congenita - drug therapy
Pain Management
Young Adult
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Summary:Pachyonychia congenita (PC) is a rare, inherited disorder of keratin filaments characterized by palmoplantar hyperkeratosis, keratoderma, and extreme pain. Management is largely symptomatic and typically involves multimodal pain control strategies. Here, we report the treatment of one 21-year-old man's refractory neuropathic PC pain with a 4-day inpatient ketamine infusion. Within 1 night of beginning treatment, his pain diminished to a 0/10 without any adverse effects, with effects lasting 2 weeks. No reported PC pain regimens have made use of intravenous ketamine; thus, we suggest recurrent ketamine infusions as an additional option in the multimodal pain regimen for patients with PC.
ISSN:2575-3126
DOI:10.1213/XAA.0000000000001066