Composite Histiocytic Sarcoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma of the Ocular Adnexa

Histiocytic sarcoma (HS) is a rare and aggressive hematologic neoplasm characterized by the proliferation of malignant histiocytes. It infrequently presents with periorbital involvement. Here we present the first documented case of ocular adnexal histiocytic sarcoma composite with chronic lymphocyti...

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Bibliographic Details
Published inOphthalmic plastic and reconstructive surgery Vol. 40; no. 5; p. e156
Main Authors Shi, Chenxu, Lytle, Andrew, Milman, Tatyana, Penne, Robert, Bagg, Adam
Format Journal Article
LanguageEnglish
Published United States 01.09.2024
Subjects
Aged, 80 and over
Eye Neoplasms - diagnosis
Eye Neoplasms - pathology
Female
Histiocytic Sarcoma - diagnosis
Histiocytic Sarcoma - pathology
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Orbital Neoplasms - diagnosis
Orbital Neoplasms - pathology
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Summary:Histiocytic sarcoma (HS) is a rare and aggressive hematologic neoplasm characterized by the proliferation of malignant histiocytes. It infrequently presents with periorbital involvement. Here we present the first documented case of ocular adnexal histiocytic sarcoma composite with chronic lymphocytic leukemia/small lymphocytic lymphoma and provide compelling evidence for the transdifferentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma to histiocytic sarcoma in an 80-year-old woman. Comprehending the clinicopathological characteristics of histiocytic sarcoma and various other histiocytic proliferations and neoplasms affecting orbital and ocular structures is imperative for ophthalmic surgeons and pathologists.
ISSN:1537-2677
DOI:10.1097/IOP.0000000000002670