Toxicological investigation of Spondias pinnata (Linn. F.) Kurz. (Family: Anacardiaceae) bark extract in Wistar rats

Context: Spondias pinnata (Linn. F.) Kurz. (Family: Anacardiaceae) is widely used in Sri Lankan traditional medicine for the treatment of diabetes mellitus. Aims: The aim was to investigate acute and subchronic toxicity of the aqueous bark extract of S. pinnata in healthy male Wistar rats. Materials...

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Published inInternational journal of green pharmacy Vol. 9; no. 1; p. 26
Main Authors Attanayake, AnojaP, Jayatilaka, KamaniA P W, Pathirana, Chitra, Mudduwa, LakminiK B
Format Journal Article
LanguageEnglish
Published Mandsaur Mandsaur Institute of Pharmacy, Mandsaur University Campus 2015
Subjects
Cholesterol
Herbal medicine
Medical research
Rodents
Toxicity
Sri Lanka
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Summary:Context: Spondias pinnata (Linn. F.) Kurz. (Family: Anacardiaceae) is widely used in Sri Lankan traditional medicine for the treatment of diabetes mellitus. Aims: The aim was to investigate acute and subchronic toxicity of the aqueous bark extract of S. pinnata in healthy male Wistar rats. Materials and Methods: Wistar rats were administered the S. pinnata bark extract (0.25-2.00 g/kg) and observed for 14 days. Subchronic dose toxicity was evaluated by daily administration of the plant extract (1.00 g/kg; optimum effective antihyperglycaemic dose in diabetic rats) to healthy Wistar rats for 30 days. Results: The extract neither produced significant changes in the consumption of food and intake of water nor affected biochemical parameters (serum lipid profile and activities of liver enzymes), hematological parameters (full blood count) and histopathology in healthy rats (P > 0.05). Conclusions: The results revealed that S. pinnata extract at a dose of 1.00 g/kg was found to be toxicologically safe as a potent antihyperglycemic agent in Wistar rats.
ISSN:0973-8258
1998-4103
DOI:10.4103/0973-8258.150918