Corneal Neurotization for Neurotrophic Keratopathy: A Multicenter Experience

• Published in: Ophthalmic plastic and reconstructive surgery Vol. 40; no. 6; p. 655
• Main Authors: Aujla, Jaskirat, Tong, Jessica Y, Curragh, David, Caplash, Yugesh, Chehade, Mark, Tumuluri, Krishna, Au, Alicia, Low, Nelson, Avisar, Inbal, Sagiv, Oded, Barequet, Irit, Ben Simon, Guy, Selva, Dinesh
• Format: Journal Article
• Language: English
• Published: United States 01.11.2024
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Cornea - innervation; Cornea - surgery; Corneal Diseases - diagnosis; Corneal Diseases - physiopathology; Corneal Diseases - surgery; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nerve Transfer - methods; Retrospective Studies; Treatment Outcome; Visual Acuity - physiology; Young Adult
• ISSN: 1537-2677
• DOI: 10.1097/IOP.0000000000002684

Corneal neurotization is an emerging technique that offers potential for visual rehabilitation in neurotrophic keratopathy. This study reports on a multicenter experience and outcomes for both direct and indirect methods of corneal neurotization. Retrospective case series. Sixteen patients with neurotrophic keratopathy who underwent corneal neurotization across 5 centers in Australia and Israel were identified for inclusion. Corneal neurotization was performed via direct neurotization from the ipsilateral or contralateral supraorbital/supratrochlear nerve or by the use of an interpositional sural nerve graft. Change in corneal sensitivity (measured in millimeters by the Cochet-Bonnet aesthesiometer), visual acuity, and corneal health. Over a mean follow-up period of 31.3 months (range: 3 months-8 years), mean corneal sensitivity improved from 3.6 mm (range: 0-25 mm) to 25.3 mm (range: 0-57 mm). Visual acuity improved on average from 20/380 to 20/260. Twelve of 16 patients (75.0%) improved in at least 2 out of the 3 main outcome measures. Nine patients (56.3%) showed an improvement in visual acuity; 13 (81.3%) showed an improvement in average corneal sensitivity; and 11 (68.8%) showed an improvement in corneal health. There were no intraoperative or postoperative complications. Corneal neurotization is an emerging surgical treatment option for the management of neurotrophic keratopathy. With appropriate case selection, outcomes are favorable and complication rates are low, for a condition that is otherwise challenging to manage. Patients with severe neurotrophic keratopathy should be considered for this surgical treatment option.