Audiovestibular Involvement in Patients With Systemic Sclerosis

• Published in: Journal of clinical rheumatology Vol. 30; no. 7; p. 276
• Main Authors: Mazeda, Carolina, Silva, Susana P, Romão, José, Matias, Daniela, Azevedo, Luísa, Barcelos, Anabela
• Format: Journal Article
• Language: English
• Published: United States 01.10.2024
• Subjects: Adult; Aged; Audiometry, Pure-Tone - methods; Case-Control Studies; Female; Hearing Loss, Sensorineural - diagnosis; Hearing Loss, Sensorineural - epidemiology; Hearing Loss, Sensorineural - etiology; Hearing Loss, Sensorineural - physiopathology; Humans; Male; Middle Aged; Prevalence; Scleroderma, Systemic - complications; Scleroderma, Systemic - diagnosis; Scleroderma, Systemic - epidemiology; Scleroderma, Systemic - physiopathology; Tinnitus - diagnosis; Tinnitus - epidemiology; Tinnitus - etiology; Tinnitus - physiopathology; Vestibular Diseases - diagnosis; Vestibular Diseases - epidemiology; Vestibular Diseases - etiology; Vestibular Diseases - physiopathology
• ISSN: 1536-7355
• DOI: 10.1097/RHU.0000000000002131

Audiovestibular dysfunction has been reported in many autoimmune connective tissue diseases, including systemic sclerosis (SSc). To assess the prevalence and features of audiological and vestibular disturbances in SSc patients and evaluate their relationship with disease duration, clinical features, nailfold videocapillaroscopy pattern, and immunologic profiles. A matched case-control study was conducted in a rheumatology clinic of a second-level hospital over 24 months. All patients underwent a detailed ear, nose, and throat examination, as well as audiometric and vestibular assessments, including pure tone audiometry, speech audiometry, immittance tests, and the Video Head Impulse Test. Thirty-five SSc patients and 24 healthy controls were included in the study. In the SSc group, subjective hearing loss was reported by 17.1% of patients, vertigo by 14.3%, tinnitus by 11.4%, and dizziness by 5.7%. Sensorineural hearing loss was identified in 42.9% of SSc patients, significantly higher than in the control group ( p = 0.013). There was no correlation between audiological manifestations and clinical symptoms, organ involvement, immunologic characteristics, and treatment. Vestibular dysfunction was detected in 60% of SSc patients, significantly higher than the control group ( p = 0.05). A significant correlation was found between abnormal Video Head Impulse Test and the presence of anti-RNA polymerase III and anti-Th/To antibodies ( p = 0.05 and p = 0.034, respectively). Our study revealed an increased prevalence of sensorineural hearing loss and vestibulopathy in SSc patients.