Downregulation of miR‐1270 mediates endothelial progenitor cell function in preeclampsia: Role for ATM in the Src/VE‐cadherin axis

• Published in: The FASEB journal Vol. 36; no. 7; pp. e22379 - n/a
• Main Authors: Schröder‐Heurich, Bianca, Büder, Tim, Meyer, Nadia, Vu, Thu Huong, Richter, Katja, Ramachandran, Dhanya, Brodowski, Lars, Kaisenberg, Constantin S., Versen‐Höynck, Frauke
• Format: Journal Article
• Language: English
• Published: United States 01.07.2022
• Subjects: ATM; cardiovascular risk; ECFC; endothelial progenitor cells; miR‐1270; preeclampsia; VE‐cadherin; endothelial progenitor cells; VE-cadherin; ATM; ECFC; cardiovascular risk; preeclampsia; miR-1270

Preeclampsia, a pregnancy‐related hypertensive disorder, is associated with endothelial dysfunction and increased cardiovascular risk of the offspring in adulthood. In preeclampsia, endothelial colony‐forming cells (ECFC) are reduced in number and function. Recently, we have shown that miR‐1270, whi...