Reduction of cesium concentration in ovine tissues following treatment with Prussian Blue labeled with 59Fe

• Published in: Health physics (1958) Vol. 71; no. 5; p. 713
• Main Authors: Ioannides, K G, Karamanis, D T, Stamoulis, K C, Mertzimekis, T J, Mantzios, A S, Nicolaou, E, Pappas, C P
• Format: Journal Article
• Language: English
• Published: United States 01.11.1996
• Subjects: Animals; Antidotes - administration & dosage; Cesium Radioisotopes - pharmacokinetics; Ferric Compounds - administration & dosage; Ferrocyanides - administration & dosage; Food Contamination, Radioactive - prevention & control; Meat; Metabolic Clearance Rate; Sheep; Tissue Distribution
• ISSN: 0017-9078
• DOI: 10.1097/00004032-199611000-00011

The effectiveness of Prussian Blue in reducing the radiocesium contamination in ovine tissues was investigated. Five ewes were fed 137Cs-contaminated wheat for 30 d. When the 137Cs concentration in milk had reached equilibrium, one animal, serving as the control, was slaughtered and the activity in its tissues was measured. Two ewes were offered daily 1 g of Prussian Blue labeled with 59Fe in the Fe(III) position, outside the complex anion. One week after the administration of Prussian Blue, these animals were slaughtered, 1 wk apart, and the level of 137Cs in their tissues was measured. Comparing the concentration of 137Cs in the blood and tissues of the Prussian Blue treated animals to the corresponding concentrations measured in the control, a considerable reduction in the radiocesium activity concentration is observed. However, 137Cs concentrations are maintained at non-zero (about 20%) values in the first 2 wk after the administration of Prussian Blue. This observation can be attributed to the fact that most of 137Cs binds to Prussian Blue in the animals' digestive tracts and the measured activity concentrations follow the elimination of cesium from tissues. Using a two-compartment mathematical model, we can predict the level of 137Cs in tissue, following the administration of Prussian Blue. Labeling Prussian Blue in the Fe(III)-position resulted in the measurement of a (2.4 +/- 0.02) % retention of Fe(III) in sheep.