The effect of subchronic inhalations of nitric oxide on metabolic processes in blood of experimental animals

Metabolic processes were investigated in plasma and erythrocytes of Wistar rats exposed to daily 10-min sessions of NO inhalation for 30 days. These included determination of glucose and lactate, catalase activity, and activities of aldehyde dehydrogenase (ALDH), lactate dehydrogenase (LDH), and cat...

Full description

Saved in:
Bibliographic Details
Published inBiomeditsinskaia khimiia Vol. 62; no. 2; p. 212
Main Authors Soloveva, A G, Peretyagin, S P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2016
Subjects
Administration, Inhalation
Aldehyde Dehydrogenase - blood
Animals
Blood - drug effects
Blood - metabolism
Blood Glucose - analysis
Catalase - blood
Dose-Response Relationship, Drug
L-Lactate Dehydrogenase - blood
Lactic Acid - blood
Male
Nitric Oxide - administration & dosage
Nitric Oxide - pharmacology
Rats, Wistar
glucose
nitric oxide
lactate
oxidoreductase
blood
Online AccessGet more information

Cover

More Information
Summary:Metabolic processes were investigated in plasma and erythrocytes of Wistar rats exposed to daily 10-min sessions of NO inhalation for 30 days. These included determination of glucose and lactate, catalase activity, and activities of aldehyde dehydrogenase (ALDH), lactate dehydrogenase (LDH), and catalase. NO inhalation in a concentration of 20 ppm, 50 ppm and 100 ppm caused an increase in glucose and lactate. Inhalation of 100 ppm NO also increased catalase activity. Inhalation of all NO concentrations resulted in a decrease of ALDH activity, while the decrease in LDH activity was observed at NO concentrations of 50-100 ppm.
ISSN:2310-6972
DOI:10.18097/PBMC20166202212