Absorption of 233U, 237Np, 238Pu, 241Am and 244Cm from the gastrointestinal tracts of rats fed an iron-deficient diet

Absorption of U, Np, Am and Cm was increased by factors of 3.4, 7.1, 2.7 and 1.7, respectively, when nitrate solutions of these actinides were gavaged to adult rats fed an iron-deficient diet. Retention increased proportionately in liver, kidney and carcass. The concentration of the actinides excret...

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Published inHealth physics (1958) Vol. 54; no. 3; p. 311
Main Authors Sullivan, M F, Ruemmler, P S
Format Journal Article
LanguageEnglish
Published United States 01.03.1988
Subjects
Americium - pharmacokinetics
Animals
Curium - pharmacokinetics
Diet
Female
Intestinal Absorption
Iron - deficiency
Neptunium - pharmacokinetics
Plutonium - pharmacokinetics
Rats
Uranium - pharmacokinetics
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Summary:Absorption of U, Np, Am and Cm was increased by factors of 3.4, 7.1, 2.7 and 1.7, respectively, when nitrate solutions of these actinides were gavaged to adult rats fed an iron-deficient diet. Retention increased proportionately in liver, kidney and carcass. The concentration of the actinides excreted also increased substantially (over that of controls) in the urine of iron-deficient rats gavaged with 233U and 237Np, but not in those with 241Am or 244Cm. Weanling rats on an iron-deficient diet, gavaged with ferric nitrate immediately before administration of 238Pu nitrate, retained between 4% and 12% of the 238Pu retained by litter mates that were not treated intragastrically with iron.
ISSN:0017-9078
DOI:10.1097/00004032-198803000-00008