Acute pancreatitis in six non-transplanted uraemic children. A co-operative study from the French Society of Paediatric Nephrology

• Published in: Pediatric nephrology (Berlin, West) Vol. 2; no. 4; p. 431
• Main Authors: Boudailliez, B, André, J L, Broyer, M, Davin, J C, Landthaler, G, Palcoux, J B
• Format: Journal Article
• Language: English
• Published: Germany 01.10.1988
• Subjects: Acute Disease; Adolescent; Amylases - blood; Child; Child, Preschool; Female; Humans; Kidney Transplantation - adverse effects; Male; Pancreatitis - complications; Pancreatitis - diagnosis; Pancreatitis - etiology; Peritoneal Dialysis, Continuous Ambulatory - adverse effects; Uremia - complications; Uremia - surgery; Uremia - therapy
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/BF00853437

Ten clinical episodes of acute pancreatitis (AP) occurred in six patients (mean age 10 years, range 3-15 years) with chronic renal failure (CRF) during a 9-year period (1977-1986). The underlying cause of CRF was vesicoureteral reflux (2); urethral valves (1); ureterohydronephrosis (1); nephronopthisis (1) and a haemolytic uraemic syndrome which occurred 12 years before (1). In all patients a diagnosis of AP was established both on clinical grounds and with a serum amylase level of greater than 600 IU/l. In 3 patients laparotomy was performed because of suspected appendicitis. All patients required exclusive parenteral feeding (mean duration 25 days) and 2 patients had a partial pancreatectomy. No patient developed pancreatic pseudocysts, 2 patients experienced one relapse (3 and 21 months later) and 1 patient had two relapses and died. Mean duration of follow up was 3 years (range 1-10 years). Possible aetiological factors were: choledochal cyst (1); parotitis without a rise in mumps antibodies (1); familial dyslipidaemia but without AP in other family members (1), and aluminium intoxication with hypercalcaemia and convulsive encephalopathy treated with valproic acid in 1 patient. Severe hyperparathyroidism with radiological signs was absent in all patients. Transplantation had been performed either before AP in 2 patients (1 and 3 years before AP) or had followed AP in 1 patient (7 years after) without occurrence or relapse of AP.