Severe scorpion envenomation: pathophysiology and the role of inflammation in multiple organ failure

Scorpion stings occur on every continent except Antarctica. The correlation between young age and severity of clinical manifestations after this envenomation is well-established. Several studies have emphasized the relevance of pro-inflammatory mediators in the pathophysiological manifestations of h...

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Published inMédecine et santé tropicales (Montrouge, France) Vol. 27; no. 2; p. 214
Main Authors Bahloul, M, Regaieg, K, Chabchoub, I, Kammoun, M, Chtara, K, Bouaziz, M
Format Journal Article
LanguageEnglish
Published France 01.06.2017
Subjects
Animals
Catecholamines - metabolism
Cytokines - metabolism
Humans
Inflammation - immunology
Inflammation - physiopathology
Multiple Organ Failure - immunology
Multiple Organ Failure - physiopathology
Scorpion Stings - immunology
Scorpion Stings - physiopathology
cytokines
inflammation
scorpion envenomation
pathophysiology
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Summary:Scorpion stings occur on every continent except Antarctica. The correlation between young age and severity of clinical manifestations after this envenomation is well-established. Several studies have emphasized the relevance of pro-inflammatory mediators in the pathophysiological manifestations of human scorpion envenomation. Moreover, there is a significant association between pro-inflammatory cytokine levels in the blood and the severity of scorpion envenomation. Release of these cytokines increases the severity of the visceral damage induced by the direct action of the venom and the activation of both the sympathetic and parasympathetic nervous systems.
ISSN:2261-2211
DOI:10.1684/mst.2017.0688