Combined effects of UFT with other anticancer agents using in vivo chemosensitivity tests

• Published in: Japanese journal of surgery Vol. 18; no. 1; p. 93
• Main Authors: Nishiyama, M, Niimi, K, Takagami, S, Hirabayashi, N, Yamaguchi, M, Saeki, T, Yoshinaka, K, Wang, D C, Niimoto, M, Hattori, T
• Format: Journal Article
• Language: English
• Published: Japan 01.01.1988
• Subjects: Animals; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cell Line, Transformed; Colonic Neoplasms - drug therapy; Drug Synergism; Esophageal Neoplasms - drug therapy; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neoplasm Transplantation; Stomach Neoplasms - drug therapy; Subrenal Capsule Assay; Tegafur - therapeutic use; Uracil - therapeutic use
• ISSN: 0047-1909
• DOI: 10.1007/BF02470852

In order to estimate the combined effects of UFT with other anticancer agents, a nude mouse experimental system (NMES), and a subrenal capsule assay (SRCA) were investigated. Three human tumor xenografts were serially transplanted into nude mice and examined. These were; EH-1 established from esophageal cancer, SH-6 from gastric cancer and CH-3 from colon cancer. The antiproliferative effects were estimated in accordance with the NCI therapeutic protocol. Significant antiproliferative effects were obtained only in NMES and a positive relationship was observed between the two assays (p less than 0.05). In the groups which were treated with a single agent, positive tumor responses were observed against mitomycin C in SH-6, against cis-DD platinum in SH-6 and EH-1, and against adriamycin in EH-1, respectively. On this study the synergistic, additive and subadditive effects were defined as the positive combined effects. The combination of MMC and UFT produced positive combined effects for all xenografts in both assays.