Enzyme-catalyzed hydrolysis of surface polycaprolactone for enhanced cell adhesion on polycaprolactone-based composite scaffolds

•A lipase treatment method for fabricating hierarchical porous scaffold.•Enhanced surface roughness, hydrophilicity, and exposure of β-TCP.•Enhanced cell adhesion compared to untreated scaffold. In this study, a porous polycaprolactone (PCL) −based scaffold was treated with lipase to create a hierar...

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Bibliographic Details
Published inMaterials letters Vol. 371; p. 136908
Main Authors Liao, Zhenhui, Liang, Lu, Ma, Liya, Wang, Limeiting, Song, Zijun, Huang, Jinhui, Yang, Hefeng
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.09.2024
Subjects
Biomaterials
Hierarchical pore
Lipase treatment
PCL-based composite
Surface
PCL-based composite
Lipase treatment
Hierarchical pore
Biomaterials
Surface
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Summary:•A lipase treatment method for fabricating hierarchical porous scaffold.•Enhanced surface roughness, hydrophilicity, and exposure of β-TCP.•Enhanced cell adhesion compared to untreated scaffold. In this study, a porous polycaprolactone (PCL) −based scaffold was treated with lipase to create a hierarchical pore structure. The lipase treatment increased the surface roughness and hydrophilicity, leading to enhanced cell adhesion compared to the untreated scaffold. The hierarchical pore structure of the lipase-treated scaffold shows promise for bone regeneration. This lipase treatment approach offers a new method for designing tissue engineering scaffolds.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2024.136908