Causes of lymphocytic meningitis in people with HIV admitted to the Infectious Disease department of Conakry

• Published in: Médecine et santé tropicales (Montrouge, France) Vol. 25; no. 1; p. 52
• Main Authors: Traoré, F A, Cissoko, Y, Tounkara, T M, Sako, F B, Mouelle, A D, Kpami, D O, Traoré, M, Doumbouya, M
• Format: Journal Article
• Language: French
• Published: France 01.01.2015
• Subjects: Adolescent; Adult; Female; Guinea - epidemiology; HIV Infections - epidemiology; Hospitalization; Humans; Male; Meningitis, Aseptic - epidemiology; Meningitis, Aseptic - microbiology; Middle Aged; Opportunistic Infections - epidemiology; Opportunistic Infections - microbiology; Retrospective Studies; Young Adult; Guinea; HIV; Guinea; cryptococcosis; lymphocytic meningitis
• ISSN: 2261-2211
• DOI: 10.1684/mst.2014.0391

The advent of HIV infection has significantly changed the distribution of the causes of lymphocytic meningitis. The objective of this study was to identify these causes among persons with HIV hospitalized in the infectious disease department of the CHU of Conakry. This retrospective study examined hospital records of patients with HIV infection admitted for lymphocytic meningitis over a 10-year period. Of the 8649 hospitalizations in the department during the study period, 3167 patients had HIV infection, and 85 of the latter were diagnosed with lymphocytic meningitis. Slightly more than half were male (sex ratio M/F = 1.1). Their mean age was 32 years. Of these 85 patients, 73 were positive for HIV-1 only and 12 for HIV1+2. A CD4 count was performed only in 13/85 patients and averaged 140 cells/mm3. The main causes associated with lymphocytic meningitis were cryptococcosis (58%), toxoplasmosis (5%), and tuberculosis (2%). Streptococcus pneumoniae, Neisseria meningitidis, and Hæmophilus influenzae were also identified in 16% of cases. In 18% of cases no microbe was identified. The overall lethality rate was 68%; it reached 100% for tuberculous meningitis and for the cases without any identified cause and was 75%-76% for the patients with toxoplasmosis and cryptococcosis. The survival rate was 100% for all bacterial causes. A cause for lymphocytic meningitis was identified in more than 81% of the patients in our series, and the most common microbe was Cryptococcus neoformans. A better microbiological technical platform and improved accessibility to treatment would enable us to provide more relevant results and treatment.