P11.13: Coronary Calcification in Young and Middle-Aged Men with Coronary Artery Disease

• Published in: Artery research Vol. 5; no. 4; pp. 195 - 196
• Main Authors: Kozlov, S. G., Balachonova, T. V., Machmudova, H. A., Belkind, M. B.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 2011; Springer Nature B.V; BMC
• Subjects: Calcification; Cardiovascular disease; Conference Abstract; Coronary vessels; Middle age; Vein & artery diseases
• ISSN: 1872-9312; 1876-4401; 1876-4401
• DOI: 10.1016/j.artres.2011.10.169

Objective To compare the presence and extent of coronary calcification in young and middle-aged patients with new onset coronary artery disease (CAD) with matched controls without a history of CAD. Methods A total of 50 men aged 28 to 50 (mean age: 43 ± 5) years with angiographically proven CAD underwent multislice computed tomography (MSCT) studies. Those with arterial hypertension, diabetes mellitus or marked hypercholesterolemia (LDL cholesterol >4.5 mmol/l) were excluded from the study. Coronary calcification wAS quantified using the Agatston score (CCS). The results were compared with a group of 30 controls without CAD, matched for sex, age, and risk factors. Results Calcifications were present in 86% of patients with CAD and in 16.7% of controls (p <0.001). The mean (SD) CCS was 285±314 in the CAD patients versus 31±129 in the controls (p <0.001). Absence of calcium, CCS of 1 to 99 (mild), 100 to 399 (moderate), and ≥400 (severe) was observed in 7 (14%), 16 (32%), 15 (30%), and 12 (24%) of the patients with CAD, and in 25 (84%), 3 (10%), 1 (3%), and 1 (3%) of the patients without CAD, respectively. Extent of coronary calcification in the CAD patients was not related to the severity of CAD. Conclusion In young and middle-aged patients with new onset CAD the presence and extent of coronary calcification is significantly greater than in matched controls.