In-vitro measurement of aerosol generated by Respimat SMI penetrating through upper airways

Respimat soft mist inhaler (SMI) is an inhaler producing a soft mist with low velocity. The liquid drug solution is emitted by the mechanical energy of compressed spring, so the device is propellant-free. This paper describes the measurement of particle fraction penetrating through the model of the...

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Bibliographic Details
Published inEPJ Web of Conferences Vol. 269; p. 1038
Main Authors Misik, Ondrej, Lizal, Frantisek, Malý, Milan, Karas, Jakub, Jedelsky, Jan, Jicha, Miroslav
Format Journal Article Conference Proceeding
LanguageEnglish
Published Les Ulis EDP Sciences 2022
Subjects
Exhalation
Fluorescein
Inhalers
Larynx
Particle deposition
Pharynx
Respiration
Trachea
Water purification
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Summary:Respimat soft mist inhaler (SMI) is an inhaler producing a soft mist with low velocity. The liquid drug solution is emitted by the mechanical energy of compressed spring, so the device is propellant-free. This paper describes the measurement of particle fraction penetrating through the model of the upper respiratory tract (mouth cavity, pharynx, larynx trachea). The solution inside the cartridge was marked by fluorescein in order to evaluate the regional particle deposition in the model. After the exposition, segments of the model, as well as the filter, were washed out and the deposited fluorescein was extracted into water. The analysis showed that the fraction of particles penetrating through the upper respiratory tract was 64.7±6.7 %. However, the real inhalation pattern was not simulated and measurement was provided with continual “inhalation” without “exhalation”.
ISSN:2100-014X
2101-6275
2100-014X
DOI:10.1051/epjconf/202226901038