Polygenic Risk Scales for the Development of Depression Using GWAS with Clinical Validation: Methodology and Study Design in the Russian Population

• Published in: Neuroscience and behavioral physiology Vol. 51; no. 8; pp. 1040 - 1049
• Main Authors: Kibitov, A. O., Mazo, G. E., Rakitko, A. S., Kasyanov, E. D., Rukavishnikov, G. V., Ilinsky, V. V., Golimbet, V. E., Shmukler, A. B., Neznanov, N. G.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2021; Springer Nature B.V
• Subjects: Behavioral Sciences; Biomedical and Life Sciences; Biomedicine; Disease prevention; Genetic screening; Mental depression; Neurobiology; Neurosciences; Population; Population studies; Preventive medicine; Prophylaxis; Quality of life; Test systems; depression; genome-wide association studies; population studies; genetic risk; prophylactic and preventive medicine; polygenic risk scores
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/s11055-021-01163-6

Depression is one of the leading causes of reduced quality of life and social functioning in patients. The prophylaxis of depression is a priority in preventive medicine. Achievement of prophylaxis requires the opportunity to detect the risk group within the population. i.e., individuals at high genetic risk of developing depression. This review describes the methodology and design of a project to develop a genetic test system based on a polygenic risk score (PRS) for developing depression taking account of the multiple ethnicity and multicultural nature of the Russian population. The study should yield the first data on the genetic architecture of depression (by the GWAS method) and produce polygenic risk scores (PRS) for developing depression. Development of a genetic test system based on studies of the Russian population in conditions of constantly decreasing costs of genetic studies will provide for an effective transition to the development of preventive medicine in mental health.