A Novel Drug Candidate for Sepsis Targeting Heparanase by Inhibiting Cytokine Storm (Adv. Sci. 29/2024)

Novel Drug Candidate for Sepsis Sepsis currently has no specific clinical treatment. The main cause of multi‐organ failure and death in sepsis is increased vascular permeability due to endothelial damage. Hongzhen Jin, Wei Zhao, Fan Yu, and co‐workers have developed a drug targeting Heparanase throu...

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Bibliographic Details
Published inAdvanced science Vol. 11; no. 29
Main Authors Wang, Danyang, Wang, Kaixuan, Liu, Qiutong, Liu, Mingyang, Zhang, Guoqiang, Feng, Ke, Wang, Kun, Ding, Xianwei, Zhu, Haomiao, Yang, Song, Liu, Yonghui, Li, Tiehai, Gong, Peng, Wang, Manli, Wang, Peng George, Jin, Hongzhen, Zhao, Wei, Yu, Fan
Format Journal Article
LanguageEnglish
Published Hoboken John Wiley and Sons Inc 07.08.2024
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Summary:Novel Drug Candidate for Sepsis Sepsis currently has no specific clinical treatment. The main cause of multi‐organ failure and death in sepsis is increased vascular permeability due to endothelial damage. Hongzhen Jin, Wei Zhao, Fan Yu, and co‐workers have developed a drug targeting Heparanase through screening. The drug significantly protects the vascular endothelial glycocalyx and improves survival rates in sepsis mouse models from 0 to 80%, making it a promising candidate for sepsis. More details can be found in article number 2403337.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202470175