12.21: Measurement of Pulse Wave Velocity in Healthy Youngsters — Reference Values and Comparison of Three Devices

• Published in: Artery research Vol. 5; no. 4; pp. 205 - 206
• Main Authors: Cseprekál, O., Kis, Kerti, A., Szabó, A. J., Benetos, A., Tulassay, T., Salvi, P., Reusz, G. S.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 2011; Springer Nature B.V; BMC
• Subjects: Conference Abstract
• ISSN: 1872-9312; 1876-4401; 1876-4401
• DOI: 10.1016/j.artres.2011.10.204

Carotid-femoral pulse wave velocity (cfPWV) is an established method for characterizing aortic stiffness. Normal PWV values for the paediatric population derived from large data collection have yet to be available. Our aim was to create a database and to assess the factors determining PWV (a) and to evaluate the comparability of cfPWV measured by oscillometry (Vicorder) with applanation tonometry (PulsePen, Sphygmocor) (b) Patients and methods: Reference tables from cfPWV obtained in 1008 healthy subjects were generated by LMS method. Effect of anthropometric data on PWV was established. cfPWV of 98 youngsters (17.2 (5.3) years) with the three devices. Results Reference tables for gender, age and height were generated. By multiple regression, age, height and blood pressure remained major predictors of PWV. (a) PWV by Vicorder was significantly lower than by Sphygmocor and PulsePen. There was no difference following path length correction of the Vicorder measurement, (6.14(0.75), 5.94(0.91) and 6.12(1.00)m/s, respectively). Bland-Altman analysis revealed excellent concordance between devices. However, there was a small but significant proportional error in the Vicorder measurements showing a trend towards lower PWV by Vicorder at higher PWV values. This study was the first to provide LMS reference tables for PWV in healthy children permitting the calculation of percentiles. Our comparative study showed that following path length correction of the Vicorder, all three devices provided comparable results. The small proportional error of Vicorder needs additional technical development to improve the accuracy of the measurements in paediatrics. Supported by OTKA-071730, TÁMOP-4.2.2-08/1/KMR-2008-0004, ETT 06-123/2009.