Efficient inactivation of SARS-CoV-2 by WHO-recommended hand rub formulations and alcohols

The recent emergence of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 is a major burden for health care systems worldwide. It is important to address if the current infection control instructions based on active ingredients are sufficient. We therefore determined the...

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Published inbioRxiv
Main Authors Kratzel, Annika, Todt, Daniel, V'kovski, Philip, Steiner, Silvio, Gultom, Mitra L, Tran Thi Nhu Thao, Ebert, Nadine, Holwerda, Melle, Steinmann, Joerg, Niemeyer, Daniela, Dijkman, Ronald, Kampf, Günter, Drosten, Christian, Steinmann, Eike, Thiel, Volker, Pfaender, Stephanie
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 17.03.2020
Subjects
Alcohols
Coronaviruses
COVID-19
Disinfectants
Disinfection
Disinfection & disinfectants
Health care
Severe acute respiratory syndrome
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Summary:The recent emergence of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 is a major burden for health care systems worldwide. It is important to address if the current infection control instructions based on active ingredients are sufficient. We therefore determined the virucidal activity of two alcohol-based hand rub solutions for hand disinfection recommended by the World Health Organization (WHO), as well as commercially available alcohols. Efficient SARS-CoV-2 inactivation was demonstrated for all tested alcohol-based disinfectants. These findings show the successful inactivation of SARS-CoV-2 for the first time and provide confidence in its use for the control of COVID-19.
DOI:10.1101/2020.03.10.986711