Morphological development of microglia in the postnatal rat brain

Morphological transformation of lectin‐positive microglia/macrophages in the developing rat cerebral hemisphere was analysed using quantitative methods. During the first postnatal month, the cells showed increases in their size and fractal dimension accompanied by a simultaneous decrease in their so...

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Bibliographic Details
Published inInternational journal of developmental neuroscience Vol. 21; no. 8; pp. 445 - 450
Main Authors Orłowski, Dariusz, Sołtys, Zbigniew, Janeczko, Krzysztof
Format Journal Article
LanguageEnglish
Published 01.12.2003
Subjects
Development
Microglia/macrophages
Quantitative morphology
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Summary:Morphological transformation of lectin‐positive microglia/macrophages in the developing rat cerebral hemisphere was analysed using quantitative methods. During the first postnatal month, the cells showed increases in their size and fractal dimension accompanied by a simultaneous decrease in their solidity. Regional variations in dynamics of the process indicated the existence of spatio‐temporal developmental gradients within the cerebral hemisphere wall which might correspond with regional patterns of neuronal differentiation. Results of the present study prove that the quantitative methods can be the source of reliable data replacing subjective cell typologies.
ISSN:0736-5748
1873-474X
DOI:10.1016/j.ijdevneu.2003.09.001