Apathy, gait slowness, and executive dysfunction (AGED) triad: opportunities to predict and delay dementia onset

• Published in: GeroScience
• Main Authors: Pieruccini-Faria, Frederico, Hachinski, Vladimir, Son, Surim, Montero-Odasso, Manuel
• Format: Journal Article
• Language: English
• Published: Switzerland 10.10.2024
• Subjects: Apathy; Gait slowness; Executive function; Vascular risk factors; Dementia
• ISSN: 2509-2723; 2509-2723
• DOI: 10.1007/s11357-024-01372-0

This study investigates whether older adults diagnosed with the apathy, gait impairment, and executive dysfunction (AGED) triad, frequently associated with cerebrovascular disease and confounded with depression, have earlier dementia onset. We followed 322 community-dwelling older individuals (mean age 72.0 ± 6.4 years; 58.3% women) free of dementia at baseline for up to 9 years. The AGED triad was identified when gait slowness (< 1 m/s), apathy (assessed by Geriatric Depression Scale-3A with ≥ 2 items), and executive dysfunction (assessed by the 75th percentile of Trail Making Test-part B by age range) were simultaneously present. Incident dementia was diagnosed using the clinical dementia rating scale. Over the 9-year follow-up (mean 45.1 ± 28.6 months), 44 participants (13.6%) converted to dementia. Sixteen participants (5.0%) were diagnosed with AGED triad + and showed a significantly higher risk of earlier conversion to dementia compared with AGED triad- (hazard ratio = 5.08, 95%CI 2.16-11.97; p = 0.0001), as well as to those with only one AGED factor or fewer AGED factors. Hypertension and diabetes were 2 and 3 times more prevalent, respectively, in individuals with AGED triad + . These findings suggest that the AGED triad serves as a simplified and effective behavioral marker for accelerated progression to dementia.