Involvement of kinases in memory consolidation of inhibitory avoidance training

• Published in: Reviews in the neurosciences
• Main Authors: Montiel, Ivan, Bello-Medina, Paola C, Prado-Alcalá, Roberto A, Quirarte, Gina L, Verdín-Ruvalcaba, Luis A, Marín-Juárez, Tzitzi A, Medina, Andrea C
• Format: Journal Article
• Language: English
• Published: Germany 27.09.2024
• Subjects: protein kinases; aversive memory; non-genomic mechanisms; intense training; long-term memory
• ISSN: 0334-1763; 2191-0200; 2191-0200
• DOI: 10.1515/revneuro-2024-0093

The inhibitory avoidance (IA) task is a paradigm widely used to investigate the molecular and cellular mechanisms involved in the formation of long-term memory of aversive experiences. In this review, we discuss studies on different brain structures in rats associated with memory consolidation, such as the hippocampus, striatum, and amygdala, as well as some cortical areas, including the insular, cingulate, entorhinal, parietal and prefrontal cortex. These studies have shown that IA training triggers the release of neurotransmitters, hormones, growth factors, etc., that activate intracellular signaling pathways related to protein kinases, which induce intracellular non-genomic changes or transcriptional mechanisms in the nucleus, leading to the synthesis of proteins. We have summarized the temporal dynamics and crosstalk among protein kinase A, protein kinase C, mitogen activated protein kinase, extracellular-signal-regulated kinase, and Ca /calmodulin-dependent protein kinase II described in the hippocampus. Protein kinase activity has been associated with structural changes and synaptic strengthening, resulting in memory storage. However, little is known about the molecular mechanisms involved in intense IA training, which protects memory from typical amnestic treatments, such as protein synthesis inhibitors, and induces increased spinogenesis, suggesting an unexplored mechanism independent of the genomic pathway. This highly emotional experience causes an extinction-resistant memory, as has been observed in some pathological states such as post-traumatic stress disorder. We propose that the changes in spinogenesis observed after intense IA training could be generated by protein kinases via non-genomic pathways.