I-2-Catalyzed transformation of o-aminobenzamide to o-ureidobenzonitrile using isothiocyanates
The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o-ureidobenzonitriles using o-aminobenzamides and isothiocyanates via intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a wi...
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Published in | Organic & biomolecular chemistry Vol. 18; no. 14; pp. 2678 - 2684 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
08.04.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o-ureidobenzonitriles using o-aminobenzamides and isothiocyanates via intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a wide variety of o-ureidobenzonitriles with excellent yields even in a scalable fashion. |
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ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/d0ob00118j |