Copper biomarkers and their relationship with parameters of insulin resistance in obese women

• Published in: Biometals
• Main Authors: da Silva, Nilmara Cunha, da Silva, Lyandra Dias, Chaves, Bianca Mickaela Santos, de Oliveira, Emyle Horrana Serafim, Barros, Esmeralda Maria Lustosa, de Oliveira, Francisco Erasmo, Henriques, Gilberto Simeone, Pereira, Irislene Costa, Severo, Juliana Soares, Dos Santos, Loanne Rocha, de Moura, Mayara Storel Beserra, da Cunha Soares, Tamires, de Sousa, Thayanne Gabryelle Visgueira, de Sousa Melo, Stéfany Rodrigues, do Nascimento Marreiro, Dilina
• Format: Journal Article
• Language: English
• Published: Netherlands 11.10.2024
• Subjects: Obesity; Insulin resistance; Copper; Nutritional status
• ISSN: 0966-0844; 1572-8773; 1572-8773
• DOI: 10.1007/s10534-024-00645-7

Some studies have demonstrated the involvement of high concentrations of copper in the manifestation of insulin resistance in individuals with obesity. The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obesity. An observational case-control clinical study involving 203 women aged between 20 and 50 years, divided into two groups: obese (n = 84) and eutrophic (n = 119). Body weight, height and waist, hip and neck circumferences, dietary copper intake, copper biomarkers, determine ceruloplasmin activity and glycemic control parameters were measured. It was observed that women with obesity had higher copper concentrations in plasma and lower concentrations in erythrocytes when compared to the control group. Analysis of glycemic control parameters revealed a statistically significant difference in fasting blood glucose (p < 0.05) between groups. The study identified a significant positive correlation between plasma copper and fasting insulin values and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (p < 0.05). The results of this study demonstrate that obese women have high copper concentrations in plasma and lower concentrations in erythrocytes. Furthermore, the significant positive correlation between plasma copper and fasting insulin and HOMA-IR index suggests the influence of this mineral on glycemic control parameters in obese women.