Synthesis and Biological Evaluation of 6-Hydroxy-4-Methyl-5,7-(Bis-p-ChlorophenylAzo) Coumarin

6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo)coumarin has been synthesized and characterized by CHN elemental analysis, FTIR, 1H-NMR-spectroscopy and mass-spectral data. Cytotoxic screening by MTT assay was carried out on the compound against breast cancer cells. The overall results from preliminar...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of applied sciences Vol. 13; no. 1; pp. 1 - 6
Main Authors Ibrahim, Dalal M., Jumal, Juliana, Harun, Farah Wahida
Format Journal Article
LanguageEnglish
Published 01.01.2016
Subjects
Breast
Cancer
Chelating
Coumarin
Electronegativity
Halogens
Screening
Synthesis
Online AccessGet full text

Cover

More Information
Summary:6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo)coumarin has been synthesized and characterized by CHN elemental analysis, FTIR, 1H-NMR-spectroscopy and mass-spectral data. Cytotoxic screening by MTT assay was carried out on the compound against breast cancer cells. The overall results from preliminary screening program revealed that the cell proliferation was highly inhibited by 6- hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo) coumarin with the value of 2.81%, at concentration of 30 mu g mL-1 compared with the untreated control cells and also possessed a good chelating activity with IC50 value 1.87 mu g mL-1. It is suggested that the cytotoxic activity is affected by hydroxyl and halogen groups as these groups have high electron affinity and high electronegativity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1546-9239
1554-3641
DOI:10.3844/ajassp.2016.1.6