Evaluation of the response to vaccination against poliomyelitis and measles in malnourished children in Morocco

• Published in: Eastern Mediterranean health journal Vol. 10; no. 4-5; pp. 474 - 481
• Main Authors: Caidi, H, Bennis, I F, Mouan, N, El Aouad, R
• Format: Journal Article
• Language: French; English
• Published: Egypt 01.07.2004
• Subjects: Age Distribution; Antibodies, Viral - blood; Antibody Formation; Case-Control Studies; Child; Child Nutrition Disorders - blood; Child Nutrition Disorders - complications; Child Nutrition Disorders - immunology; Child, Preschool; Female; Humans; Immunization Schedule; Infant; Male; Measles - complications; Measles - epidemiology; Measles - prevention & control; Measles virus - immunology; Morocco - epidemiology; Poliomyelitis - complications; Poliomyelitis - epidemiology; Poliomyelitis - prevention & control; Poliovirus - immunology; Protein-Energy Malnutrition - blood; Protein-Energy Malnutrition - complications; Protein-Energy Malnutrition - immunology; Seroepidemiologic Studies; Sex Distribution; Treatment Failure; Vaccination - standards; Morocco
• ISSN: 1020-3397; 1020-3397; 1687-1634
• DOI: 10.26719/2004.10.4-5.474

We made a comparative survey of the poliovirus antibodies (anti-poliovirus type 1, anti-poliovirus type 2 and anti-poliovirus type 3) and the measles antibodies in malnourished but completely vaccinated children (37) and control children (34). The age range was 10 months to 5 years. Immunization in children with protein-energy malnutrition was low for both vaccines. Seroprevalence rates of the polio 1, polio 2, polio 3 antibodies and the measles antibodies in the control group were 94.1%, 97.1%, 91.2% and 82.4% respectively. In malnourished children the respective rates were in some cases significantly lower being: 40.5% (P = 0.001), 59.5% (P = 0.001), 40.5% and 35.1%. Malnutrition is a major determinant of the humoral response to oral polio and measles vaccines and must be given due consideration to prevent vaccination failure.