Multifunctional emulsion for potential wound-healing applications: A development for co-administration of essential vitamins, silver nanoparticles, and potent active ingredients

This research explores the formulation of novel oil-in-water emulsion designed for the co-delivery of compounds with different properties that jointly represent an exceptional system to apply in skin regeneration, such as essential vitamins A and E, silver nanoparticles, silver sulfadiazine, and lid...

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Bibliographic Details
Published inJournal of drug delivery science and technology Vol. 101; p. 106128
Main Authors Sosa, Ayelen M., Igartúa, Daniela E., Martínez, Luis M., Alonso, Silvia del V., Prieto, María J., Martinez, Carolina S.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2024
Subjects
Antimicrobial capacity
Emulsions
Silver nanoparticles
Vitamins
Wound healing
Emulsions
Wound healing
Antimicrobial capacity
Silver nanoparticles
Vitamins
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Summary:This research explores the formulation of novel oil-in-water emulsion designed for the co-delivery of compounds with different properties that jointly represent an exceptional system to apply in skin regeneration, such as essential vitamins A and E, silver nanoparticles, silver sulfadiazine, and lidocaine. First, the preparation method of emulsions was optimized, characterizing their stability over storage time. Emulsions, which were prepared with certain stirring speed and time, presented the lower droplet size and the higher stability for 28 days. Second, the active ingredients were incorporated into the optimized emulsion, and their stability and antimicrobial capacity were evaluated. In addition to being a stable colloidal system, the emulsion with active ingredients demonstrated antimicrobial effects against Pseudomonas aeruginosa and Staphylococcus aureus (both usually present in skin wounds). The antimicrobial properties of silver nanoparticles and the healing-promoting characteristics of vitamins make this combination promising for applications in pharmaceutical and cosmetic formulations. Utilizing natural oils and biocompatible components aligns with sustainable and health-conscious product development trends. The findings of this study hold implications for diverse applications in medicine and cosmetics. [Display omitted]
ISSN:1773-2247
DOI:10.1016/j.jddst.2024.106128