A Case-Control Study of TP53 R72P Polymorphism in the Breast Cancer Patients of Ethnic Kashmiri Population

• Published in: World journal of oncology Vol. 1; no. 6; pp. 236 - 241
• Main Authors: Syeed, Nidda, Sameer, A Syed, Abdullah, Safiya, Husain, Syed Akhtar, Siddiqi, Mushtaq A
• Format: Journal Article
• Language: English
• Published: Canada Elmer Press 01.12.2010
• Subjects: Original; Breast cancer; Kashmir; R72P; Tp53 polymorphism
• ISSN: 1920-4531; 1920-454X
• DOI: 10.4021/wjon261w

TP53 R72P polymorphism has been proposed as a risk factor for breast cancer and is more likely to differ among different ethnic populations. We carried out the study to determine the role of R72P polymorphism in breast cancer patients of Kashmir, an ethnic population by PCR-RFLP. To evaluate the role of this polymorphism in our ethnic Kashmiri population, we devised our study to study its role in breast cancer patients and healthy controls. The contribution of TP53 R72P polymorphism in 130 breast cancer patients and 220 female healthy controls was assessed using a PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism). We observed that women with PP genotype have increased risk for developing breast cancer. We found Pro/Pro genotype statistically significantly associated with dwelling, lymph node metastases, histopathological grade, and menopausal status. Pro/Pro genotype in cases and controls was observed and it was found that it is significantly associated with the breast cancer. Our findings suggest that TP53 R72P polymorphism is a risk factor in breast cancer. Furthermore, these results suggest Pro72 allele is associated with higher risk for breast cancer patients. Women with PP genotype have increased risk for developing breast cancer.