Effect of Various Sweeteners on Glycogen Content of Blood Leukocytes and Differential Leukocyte Count in C57BL/6 Mice

The effect of stevia leaf extract, saccharinate, and cyclamate in various dosages on the glycogen content of blood leukocytes in C57BL/6 mice as a necessary substrate for the realization of phagocytosis was studied. An increase in glycogen content was found in all experimental groups treated with sw...

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Bibliographic Details
Published inMoscow University biological sciences bulletin Vol. 78; no. 4; pp. 263 - 267
Main Authors Kizhina, A. G., Maschinskas, M. S., Panova, E. V., Ilyukha, V. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.12.2023
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Body weight
Cell Biology
Dosage
Glycogen
Leaves
Leukocytes (neutrophilic)
Life Sciences
Lymphocytes
Phagocytosis
Plant extracts
Plant Sciences
Short Communications
Sweeteners
Zoology
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Summary:The effect of stevia leaf extract, saccharinate, and cyclamate in various dosages on the glycogen content of blood leukocytes in C57BL/6 mice as a necessary substrate for the realization of phagocytosis was studied. An increase in glycogen content was found in all experimental groups treated with sweeteners at a dosage of 10 mg/g of body weight. The effect of sweeteners on the differential leukocyte counts was found only in mice receiving the stevia leaf extract at a dosage of 10 mg/g of body weight manifested as an increase neutrophil-to-lymphocyte ratio (NLR). The data obtained expand our understanding of the metabolism of sugar substitutes in an organism and their influence on physiological systems, in particular, the hematopoietic and immune systems.
ISSN:0096-3925
1934-791X
DOI:10.3103/S0096392524600443