An Efficient Synthetic Method for the Synthesis of Novel Pyrimido[1,2-a]pyrimidine-3-carboxylates: Comparison of Microwave and Conventional Heating

A very simple and efficient procedure for the synthesis of novel pyrimido[1,2-a]pyrimidine derivatives is described. Thermal cyclization reactions of 2-aminopyrimidine and its substituted derivatives with diethyl ethoxymethylenemalonate (EMME) have been investigated. Conventional heating and microwa...

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Bibliographic Details
Published inPolycyclic aromatic compounds Vol. 42; no. 8; pp. 4948 - 4964
Main Authors Bayramoğlu, Duygu, Güllü, Mustafa
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 14.09.2022
Taylor & Francis Ltd
Subjects
2-aminopyrimidine
Carboxylates
Chemical reactions
Heating
Infrared spectroscopy
Irradiation
Mass spectroscopy
microwave assisted reactions
multicomponent reactions
NMR
Nuclear magnetic resonance
Pyrimido[1,2-a]pyrimidine
quinolones antibiotics
Synthesis
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Summary:A very simple and efficient procedure for the synthesis of novel pyrimido[1,2-a]pyrimidine derivatives is described. Thermal cyclization reactions of 2-aminopyrimidine and its substituted derivatives with diethyl ethoxymethylenemalonate (EMME) have been investigated. Conventional heating and microwave irradiation (MW) conditions were applied to enable the comparison of both techniques on the obtained products. Besides the effect of different reaction parameters and the substituents on the conversion reactions have been also investigated in detail. Structural analyses of all compounds synthesized with high yields have been carried out by suitable spectroscopic methods (FT-IR, NMR, mass spectroscopy, LC-MS TOF).
ISSN:1040-6638
1563-5333
DOI:10.1080/10406638.2021.1915806