Small Fiber Neuropathy

Small fiber neuropathy (SFN), despite a thirty-year history of study, remains one of the most mysterious diseases that are difficult to diagnose and treat. The prevalence of SFN is 52.95 per 100 000 population; diabetes mellitus is considered to be the most frequent cause of this disease. Chronic ne...

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Bibliographic Details
Published inHuman physiology Vol. 44; no. 8; pp. 838 - 843
Main Authors Suponeva, N. A., Belova, N. V., Zaitseva, N. I., Yusupova, D. G., Lagoda, D. Yu, Korepina, O. S., Piradov, M. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.12.2018
Springer Nature B.V
Subjects
Autonomic nervous system
Biomedical and Life Sciences
Biomedicine
Diabetes mellitus
Diabetic neuropathy
Fibers
Human Physiology
Life Sciences
Pain perception
Quality of life
Sensory neurons
quantitative sudomotor axon reflex test (QSART)
small fiber neuropathy (SFN)
peripheral neuropathy
channelopathy
skin biopsy
quantitative sensory testing (QST)
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Summary:Small fiber neuropathy (SFN), despite a thirty-year history of study, remains one of the most mysterious diseases that are difficult to diagnose and treat. The prevalence of SFN is 52.95 per 100 000 population; diabetes mellitus is considered to be the most frequent cause of this disease. Chronic neuropathic pain syndrome, temperature sensation abnormalities, and autonomic disorders develop as a result of damage to fine myelinated Аδ- and unmyelinated C fibers. The disease mainly spreads in the upward direction: from feet to the proximal parts of the body and arms; primary axonal damage takes place. Although SFN is believed to be one of the most “benign” types of neuropathy as it does not involve the large sensory and motor fibers, patients’ quality of life is markedly reduced.
ISSN:0362-1197
1608-3164
DOI:10.1134/S0362119718080121