Chromatographic Methods for the Analysis of the Antipsychotic Drug Clozapine and Its Major Metabolites: A Review

Clozapine (CLZ), a second-generation antipsychotic, can effectively reduce schizophrenia, bipolar disorder and major depression symptoms. This review provides an overview of all reported chromatographic methods (62 references) for the quantification of CLZ and its two main metabolites, norclozapine...

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Bibliographic Details
Published inJournal of chromatographic science
Main Authors Hrichi, Hajer, Kouki, Noura, Elkanzi, Nadia Ali Ahmed
Format Journal Article
LanguageEnglish
Published United States 04.04.2024
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Summary:Clozapine (CLZ), a second-generation antipsychotic, can effectively reduce schizophrenia, bipolar disorder and major depression symptoms. This review provides an overview of all reported chromatographic methods (62 references) for the quantification of CLZ and its two main metabolites, norclozapine and clozapine N-oxide in pharmaceutical formulations, biological matrices and environmental samples.
ISSN:1945-239X
DOI:10.1093/chromsci/bmae016