Electro-clinical relationship and source analysis of absence seizures in childhood

• Published in: Revista mexicana de neurociencia Vol. 23; no. 3; pp. 86 - 91
• Main Authors: Aguilar-Fabré, Liane, Rodríguez-Valdés, René F., Galán-García, Lídice, Bosch-Bayard, Jorge F., Hernández-Montiel, Hebert L., García-García, Ramiro J.
• Format: Journal Article
• Language: English
• Published: Academia Mexicana de Neurología A.C 01.07.2022; Permanyer
• Subjects: Absence seizures. VARETA. Source analysis; Clinical Neurology; Neurosciences; VARETA; Absence seizures; Análisis de fuentes; Source analysis; Crisis de ausencia
• ISSN: 2604-6180; 2604-6180
• DOI: 10.24875/RMN.21000049

Abstract Purpose: This study was to deepen into the electro-clinical relationship and source analysis of absence seizures in childhood. Methods: Thirty-three subjects were studied with clinical and electrophysiological diagnosis of absence seizures without antiepileptic medication, video-electroencephalogram was applied. We obtained clinical behavior and electrophysiological variables during seizures and General Linear Model was applied, with p < 0.05. Source analysis was carried out with VARETA method. Results: 174 seizures were evaluated. 75.75% showed interictal epileptiform discharges (IED) and 12.12% showed posterior delta activity. There was an unequal behavior in relation with total electro-clinical seizures and presence or no of IED (p = 0.02), namely between subjects without IED in EEG and multifocal EEG (p = 0.008). Quantity of seizures recorded during HPV had a different behavior between subjects without IED in EEG and multifocal EEG (p = 0.03) and between focal and multifocal EEG (p = 0.04). Source analysis (VARETA) evidence the onset frontal of seizures in 57.47%, mesial and dorsolateral regions in 43% and 57%, respectively. Conclusion: These data suggest that absence seizures are not “generalized” if we considered global cortical activation but rather involve localized discharges from specific cortical regions, mainly frontal lobe.