Serum profiles of circulating granulocyte-macrophage colony-stimulating factor in acute myocardial infarction and relation with post-infarction left ventricular function

• Published in: Chinese medical journal Vol. 118; no. 18; pp. 1557 - 1559
• Main Authors: Ma, Yi-tong, Fu, Zhen-yan
• Format: Journal Article
• Language: English
• Published: China Cardiovascular Research Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China 20.09.2005
• Subjects: Adult; Aged; Female; Granulocyte-Macrophage Colony-Stimulating Factor - blood; Humans; Male; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - physiopathology; Ventricular Function, Left; 刺激因子; 巨噬细胞; 心室功能; 心肌梗塞; 粒性白细胞; 血液循环; colony-stimulating factor; remodeling; granulocyte-macrophage; myocardial infarction
• ISSN: 0366-6999; 2542-5641

Accumulating evidence indicates that inflammation plays an important role in cardiac repairing and remodeling after acute myocardial infarction （AMI）, process of which is mediated by a cytokine reaction cascade. 1 Granulocytemacrophage colony-stimulating factor （GM-CSF） is a cytokine, which belongs to the family of haemopoietic cell colony-stimulating factor and regulates the proliferation and differentiation of myeloid progenitor cells. In addition to its growthpromoting effects, this pro-inflammation cytokine stimulates the function of mature neutrophils, monocytes and eosinophils, including regulation of leukocyte adhesion, augmentation of surface antigen expression, superoxide anion generation, enhancement or induction of other cytokine production.